Due to significant differences in blood composition among species, humans, dogs, and cats vary in terms of hematocrit levels, plasma composition, and glucose distribution. For example, compared to humans, glucose in dogs and cats is predominantly distributed in the plasma, with a lower proportion present in red blood cells, and the overall composition of blood components also differs.

These differences directly affect the electrochemical reactions and calibration algorithms used by blood glucose meters, meaning that the same glucose concentration may yield different readings across species. Therefore, veterinary glucose meters are typically designed with species-specific settings, such as dog and cat modes, to calibrate measurements according to the unique blood characteristics of each species.

If the correct animal mode is not selected during use, the measured glucose values may be systematically higher or lower than the actual levels, potentially impacting clinical evaluation and treatment decisions. Hence, when performing blood glucose monitoring in pets, ensuring the correct species setting (e.g., dog or cat) is selected is essential for obtaining accurate results.